Dose Response Study of Intrathecal Morphine for Off-Pump Coronary Artery Bypass Grafting: a pilot Prospective Randomized Double-Blinded Controlled Clinical Trial
نویسندگان
چکیده
Interventions: Patients were randomized to receive 2.5μg/kg (ITM-2.5) or 5μg/kg (ITM-5) intrathecal morphine or sham-control preoperatively. Anaesthesia was induced and maintained with sufentanil (limited to 1μg/kg), propofol, rocuronium and isoflurane. Blinded observer-caregivers extubated the patients using protocol-defined criteria, and on-demand intravenous morphine (IVM) was administered to patients using a standardized protocol.
منابع مشابه
بررسی مقایسه‌ای اثر تزریق 2 دوز مورفین اینتراتکال بر زمان خروج لوله نای پس از جراحی پیوند عروق کرونر
The object of the present study was to determine the effect of 2 doses of intrathecal morphine on extubation time and on postoperative analgestic requirements after coronary artery bypass graft surgery. This prospective, randomized, double blind placebo-control study was carried out on 60 adult patients(ASA II, ASA III) without emergency surgery, valvular heart disease, contraindication...
متن کاملRationale, design and methodology for a Prospective Randomized Study of graft patency in Off-pump and On-pump MultI-Vessel coronary artery bypasS Surgery (PROMISS) using multidetector computed tomography
BACKGROUND Off-pump coronary artery bypass grafting has been accused of possibly compromising graft patency. Sixteen slice computed tomography has shown good diagnostic accuracy in the assessment of coronary bypass graft patency when compared with conventional coronary artery angiography and is less invasive. The study hypothesis is that coronary artery bypass grafting (CABG) performed without ...
متن کاملOff-Pump Versus On-Pump Coronary Artery Bypass Graft Surgery, prospective cohort study
Introduction: Coronary artery bypass grafting is a surgical operation that bypasses atherosclerotic coronary vessels and restores blood flow to the ischemic zone of hearts. And two different conventional methods are ON-pump CABG, and Off-pump CABG. Altogether, the efficacy and safety of these two types of surgical procedures are still under debate. In this study, we aim to com...
متن کاملImpact of Dexmedetomidine on Hemodynamic Changes during and after Coronary Artery Bypass Grafting
OBJECTIVE To determine the effect of dexmedetomidine (Dex) on hemodynamic changes during cardiopulmonary pump and postoperative period in coronary artery bypass grafting (CABG). METHODS AND DESIGN This study is designed as a double-blinded, randomized clinical trial. SETTING University hospital and single center. PARTICIPANTS patients candidate for elective CABG. INTERVENTION Dex 0.5 μg...
متن کاملAvoidance of Dialysis in an End-Stage Renal Disease Patient Status-post Off-pump Coronary Artery Bypass Grafting
Certain benefits are clearly associated with the use of off-pump coronary artery bypass grafting (CABG) as compared with the on-pump CABG. The superiority is more evident in patients with multiple co morbidities including renal failure.We reviewed the medical records of a 67-year-old male with a past medical history that was significant for multiple cardiovascular diseases and new-onset end-sta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017